Macflor 200

Florfenicol is a broad-spectrum antibiotic used exclusively in veterinary medicine to treat a wide range of bacterial infections in farm animals and aquaculture. It is a synthetic analog of chloramphenicol but lacks the nitro group associated with fatal aplastic anemia in humans, making it safer for use in food-producing animals.
1. Florfenicol 20%
2. Florfenicol 30%
3. Florfenicol injection

Mechanism of action
Inhibits protein synthesis: Florfenicol works primarily by binding to the 50S ribosomal subunit of bacteria.
Blocks peptidyl transferase: By attaching to the ribosome, it inhibits the enzyme peptidyl transferase, which is essential for protein synthesis. Bacteriostatic and bactericidal effects: The drug is primarily bacteriostatic (it prevents bacteria from reproducing) but can be bactericidal (kills bacteria) at higher concentrations against certain pathogens.

Common veterinary uses: Florfenicol is highly lipophilic, allowing it to penetrate tissues and cross biological barriers effectively. It is used to treat various infections in:

Cattle: Bovine respiratory disease (BRD) caused by Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni. Foot rot caused by Fusobacterium necrophorum and Bacteroides melaninogenicus. Infectious bovine keratoconjunctivitis.

Swine: Swine respiratory disease caused by Actinobacillus pleuropneumoniae and Pasteurella multocida. Other infections, such as those caused by Salmonella and Streptococcus suis.

Aquaculture (fish): Control of diseases like enteric septicemia in catfish and furunculosis in salmon.

Poultry: Respiratory and gastrointestinal tract infections, including colibacillosis, salmonellosis, and fowl cholera.

Dosage & Administration:
The route and duration of florfenicol administration vary by animal species and the specific infection being treated. It is available in several forms, including:
Injectable solutions (intramuscular or subcutaneous)
Oral solutions (for drinking water)
Medicated feed or granules

Potential side effects: The use of florfenicol can cause side effects, though the frequency and severity vary. Some of the common and serious adverse effects include:

Digestive issues: Decreased food and water consumption, diarrhea, and transient softening of feces.
Reproductive toxicity: Studies in laboratory animals have shown potential reproductive and developmental toxicity, and the drug should not be used in breeding animals.

Bone marrow suppression: Prolonged use can cause dose-dependent, reversible bone marrow suppression.

Injection site reactions: Intramuscular or subcutaneous injections can cause localized swelling and inflammation.

Resistance development: Inappropriate use can lead to antibiotic resistance, which can spread to other bacteria and animal species.

Important precautions:

Withdrawal periods: To prevent drug residues in the food supply, strict withdrawal periods must be observed before slaughtering treated animals.

Breeding animals: Do not use in animals intended for breeding purposes.

Dairy cattle: Do not use in female dairy cattle 20 months of age or older, as it can cause drug residues in milk.

Human contact: Direct contact with the drug should be avoided. Pregnant women should handle it with caution, as it can be irritating to the skin and eyes.

This is for informational purposes only. For medical advice or a diagnosis, consult a professional. AI responses may include mistakes